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Therefore, the recommended Ambien dosage is 5 mg in such patients to decrease the possibility of side effects. Use in the elderly and/or debilitated patients: Impaired motor and/or cognitive performance after repeated exposure or unusual sensitivity to sedative/hypnotic drugs is a concern in the treatment of elderly and/or debilitated patients.
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Recommendations for the use.
Way of use and dosage.
- During the treatment it is necessary to refrain from potentially dangerous activities that require concentration, attention and high psychomotor speed. Side effects.
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*Materials which are provided in this article have an informative character and are not a direction for the obligatory use.
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Zolpidem (Stilnox, Ambien) belongs to a group of medicines called hypnotics (sleep producers). These medicines work by acting on the brain to.
The GABA A receptor is a pentameric ligand-gated ion channel. Upon activation, it selectively conducts Cl- through its pore, resulting in hyperpolarization of the neuron which reduces cell excitability.
Recommended initial dose is 5 mg for woman and 5-10 mg for men, immediay before bedtime with at least 7-8 hours remainingbefore the planed time of awakening.
Other possible side effects include: headache, nausea, vomiting, amnesia, agitation, nightmares and fatigue.
Sleeping problems do not usually last long and most people only need a short course of treatment. Zolpidem may be used for short-term treatment of insomnia.
The most common adverse effects are daytime drowsiness, dizziness and diarrhea.
Geriatric patients and patients with hepatic impairment: Recommended dose is 5 mg for men and women.
Zolpidem binds with high affinity to GABA A receptors containing an alpha-1 subunit (also known as BZ1- or w 1-receptor subtypes), leading to a positive allosteric modulation that increase the affinity of γ-aminobutyric acid (GABA) to GABA A receptors. Zolpidem is an hypnotic drug with short duration of action (up to 6 hours), chemically unrelated to the benzodiazepines.
The effect of zolpidem may be slowed if taken with or immediay after a meal.
Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Insomnia is a difficulty in falling asleep or sleeping properly.
Zolpidem has both a rapid absorption and onset of hypnotic action if taken on an empty stomach and a short elimination half-life (2-3 hours).